Encouragement of Super-aggressive LDL-lowering Therapies

Lipid-lowering therapies and achievement of LDL-cholesterol targets

In the present issue of Archives of Medical Science, Mark et al. [1] report the results of a survey conducted last year in Hungary. This consisted of 1,626 adult patients with high cardiovascular (CV) risk, due to unstable angina (23%), peripheral artery disease (17%), previous myocardial infarction (34%), stroke (30%) or transient ischemic attack (17%). The main aim of the study was to assess ...

PCSK9 inhibitors for LDL lowering.

The Success Story of LDL Cholesterol Lowering.

We can look back at >100 years of cholesterol research that has brought medicine to a stage where people at risk of severe or fatal coronary heart disease have a much better prognosis than before. This progress has not come about without resistance. Perhaps one of the most debated topics in medicine, the cholesterol controversy, could only be brought to rest through the development of new clini...

Molecular Targeted Therapies of Aggressive Thyroid Cancer

Differentiated thyroid carcinomas (DTCs) that arise from follicular cells account >90% of thyroid cancer (TC) [papillary thyroid cancer (PTC) 90%, follicular thyroid cancer (FTC) 10%], while medullary thyroid cancer (MTC) accounts <5%. Complete total thyroidectomy is the treatment of choice for PTC, FTC, and MTC. Radioiodine is routinely recommended in high-risk patients and considered in inter...

Current therapies for lowering lipoprotein (a).

Lipoprotein (a) [Lp(a)] is a human plasma lipoprotein with unique structural and functional characteristics. Lp(a) is an assembly of two components: a central core with apoB and an additional glycoprotein, called apo(a). Ever since the strong association between elevated levels of Lp(a) and an increased risk for CVD was recognized, interest in the therapeutic modulation of Lp(a) levels has incr...